| Primary Identifier | MGI:1913590 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 66340 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables endopeptidase activator activity and molecular function inhibitor activity. Involved in several processes, including cellular response to glucose starvation; negative regulation of TORC1 signaling; and positive regulation of endopeptidase activity. Acts upstream of or within Notch receptor processing. Part of gamma-secretase complex. Is expressed in early tubule; female associated reproductive structure; male associated reproductive structure; ovary; and testis. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit). PHENOTYPE: Homozygous mutation of this gene results in lethality before weaning. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
