| Primary Identifier | MGI:105367 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 16190 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable interleukin-4 receptor activity. Involved in positive regulation of chemokine production; positive regulation of cold-induced thermogenesis; and positive regulation of macrophage activation. Predicted to be located in extracellular region and membrane. Predicted to be part of signaling receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including adrenal medulla; blastocyst-stage conceptus; hemolymphoid system; medulla oblongata basal plate mantle layer; and reproductive system. Used to study asthma. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; multiple sclerosis (multiple); renal tuberculosis; and rheumatoid arthritis. Orthologous to human IL4R (interleukin 4 receptor). PHENOTYPE: Nullizygous mice exhibit reduced T helper 2 cell response to N. brasiliensis infection. Homozygotes for a null allele also display severe susceptibility to S. mansoni infection, enhanced carcinogen-induced intestinal tumour initiation, and altered control of chronic Leishmania major infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
