| Primary Identifier | MGI:1346859 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 26417 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables MAP kinase activity and phosphotyrosine residue binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; negative regulation of cholesterol efflux; and nervous system development. Acts upstream of or within several processes, including Bergmann glial cell differentiation; ERK1 and ERK2 cascade; and respiratory system development. Located in cytosol; nucleus; and pseudopodium. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; limb primordium; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Parkinson's disease; carcinoma (multiple); and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). PHENOTYPE: Mice homozygous for a targeted null mutation are hyperactive with impaired T cell maturation and proliferation. Mice homozygous for a knock-out allele on a CD-1 background exhibit normal Mendelian ratios, growth, and no obvious abnormalities. Adult mice heterozygous for a knock-out allele show no significant brain neuroanatomical phenotypes or male-specific behavioral deficits. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
