| Primary Identifier | MGI:1334446 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 19663 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable several functions, including RNA binding activity; protein homodimerization activity; and transcription coactivator activity. Predicted to be involved in several processes, including SMAD protein signal transduction; regulation of alternative mRNA splicing, via spliceosome; and response to oxidative stress. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleoplasm. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and retina. Orthologous to human RBPMS (RNA binding protein, mRNA processing factor). PHENOTYPE: Mice homozygous for one null allele exhibit cardiomyocyte binucleation, noncompaction cardiomyopthy, patent ductus arteriosus, and postnatal lethality by P4. Mice homozygous for a second null allele display partial premature death with increased cardiomyocyte binucleation and dilated intestines. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
