| Primary Identifier | MGI:109452 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 17125 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and primary miRNA binding activity. Involved in several processes, including SMAD protein signal transduction; osteoblast differentiation; and positive regulation of miRNA transcription. Acts upstream of or within several processes, including brain development; regulation of gene expression; and skeletal system development. Located in cytoplasm. Part of transcription regulator complex. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human SMAD1 (SMAD family member 1). PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired allantois formation resulting in the lack of a placenta, and die around embryonic day 9-10. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
