| Primary Identifier | MGI:103262 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 22601 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; proline-rich region binding activity; and transcription coactivator activity. Involved in several processes, including cardiac muscle tissue regeneration; positive regulation of Notch signaling pathway; and positive regulation of cardiac muscle cell proliferation. Acts upstream of or within several processes, including epithelial cell differentiation; regulation of epithelial cell differentiation; and tube morphogenesis. Located in cell-cell junction; cytosol; and membrane. Part of transcription regulator complex. Is active in nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; eye; and ovary. Used to study cone dystrophy. Human ortholog(s) of this gene implicated in uveal coloboma-cleft lip and palate-intellectual disability. Orthologous to human YAP1 (Yes1 associated transcriptional regulator). PHENOTYPE: Embryos homozygous for a null mutation of this gene die between embryonic days E9.5 and E10.5 due to yolk sac avasculogenesis and failure of attachment between the allantois and the chorion. Heterozygous mice are viable, and fertile but exhibit age-dependent cone photoreceptor degeneration and retinal abnormalities. An inducible acetylation-blocking allele leads to improved post-injury cardiac regeneration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
