| Primary Identifier | MGI:104661 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 19883 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; beta-catenin binding activity; and transcription coactivator binding activity. Involved in several processes, including cerebellar granule cell precursor proliferation; cholesterol homeostasis; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to cytokine stimulus; cerebellar Purkinje cell differentiation; and nitric oxide biosynthetic process. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in allergic rhinitis; childhood-onset asthma; chronic obstructive pulmonary disease; lung non-small cell carcinoma; and nocturnal asthma. Orthologous to human RORA (RAR related orphan receptor A). PHENOTYPE: Homozygotes for null mutations exhibit ataxia, cerebellar dysgenesis, impaired Purkinje and granule cell development, olfactory defects, hypoalphalipoproteinemia, and death around 4 weeks. Heterozygotes show slow Purkinje cell dedritic atrophy and loss. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
