| Primary Identifier | MGI:99694 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 19417 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables glutamate receptor binding activity. Involved in neuron projection development and regulation of intracellular signal transduction. Acts upstream of or within cell population proliferation; regulation of NMDA receptor activity; and regulation of neuronal synaptic plasticity. Located in cytosol and growth cone. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Orthologous to human RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1). PHENOTYPE: Homozygotes for null mutations (and heterozygotes with a paternally inherited mutant allele) exhibit reduced postnatal growth, low insulin and IGF I levels, glucose intolerance, beta-cell hypoplasia, impaired long-term synaptic plasticity, and impaired hippocampal-dependent learning. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
