| Primary Identifier | MGI:96837 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 17002 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables peptidase activity. Predicted to be involved in several processes, including defense response to bacterium; defense response to symbiont; and regulation of tumor necrosis factor superfamily cytokine production. Located in cytoplasm. Is expressed in several structures, including early embryo; epithelium; genitourinary system; gut; and liver. Human ortholog(s) of this gene implicated in candidiasis; lung non-small cell carcinoma; and renal cell carcinoma. Orthologous to human LTF (lactotransferrin). PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile, and grossly normal and exhibit only minor alterations in iron homeostasis. Mice homozygous for a different knock-out allele show increased susceptibility to inflammation-induced colorectal dysplasia along with increased cell proliferation and decreased apoptosis in colonic tissues. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
