| Primary Identifier | MGI:1343054 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 108062 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable mRNA binding activity. Predicted to be involved in mRNA 3'-end processing and regulation of mRNA 3'-end processing. Predicted to be located in cleavage body. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex and mRNA cleavage stimulating factor complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex ventricular layer; and cortical plate. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human CSTF2 (cleavage stimulation factor subunit 2). PHENOTYPE: Embryonic stem cells (ESCs) hemizygous for a gene trap allele show a specific loss of differentiation potential toward the endodermal lineage and a severe defect in cardiomyocyte differentiation. Mutant ESCs differentiated into embryoid bodies fail to cavitate. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
