| Primary Identifier | MGI:96281 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 15560 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables G protein-coupled serotonin receptor activity. Involved in several processes, including behavioral fear response; phospholipase C-activating serotonin receptor signaling pathway; and regulation of corticotropin-releasing hormone secretion. Acts upstream of or within positive regulation of calcium-mediated signaling and positive regulation of fat cell differentiation. Predicted to be located in external side of plasma membrane. Predicted to be part of G protein-coupled serotonin receptor complex. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; heart; and sensory organ. Used to study Prader-Willi syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma; bipolar disorder; obesity; and schizophrenia. Orthologous to human HTR2C (5-hydroxytryptamine receptor 2C). PHENOTYPE: Homozygotes for a targeted null mutation exhibit hyperactivity, hyperphagia, reduced energy cost of locomotion, late-onset obesity, insulin resistance, and altered responses to cocaine. Mutants are also subject to spontaneous death from seizures. Homozygosity for the p.F328L affects serotonin signaling, leading to impaired plasticity of hippocampal ventral CA1 neurons and short term-memory deficits. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
