| Primary Identifier | MGI:95856 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 14859 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables glutathione transferase activity. Involved in ureteric bud development. Acts upstream of or within aflatoxin catabolic process. Located in cytosol and mitochondrion. Is expressed in alimentary system; liver; nervous system; nose; and urinary system. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3). PHENOTYPE: Targeted disruption of this gene does not alter viability, fertility or general health. However, adult homozygous mutant mice exhibit increased sensitivity to the acute cytotoxic and genotoxic effects of aflatoxin B1, a major risk factor for hepatocellular carcinoma in humans. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
