| Primary Identifier | MGI:88268 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 12346 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable arylesterase activity; carbonate dehydratase activity; and cyanamide hydratase activity. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and skeleton. Used to study major depressive disorder. Orthologous to human CA1 (carbonic anhydrase 1). PHENOTYPE: This locus controls electrophoretic variation in red blood cells. The a allele determines a slow migrating form in C57BL/6, C3H/He and other strains; the b allele determines a fast form in IS/Cam, WB/Re, SM, M. m. castaneus and M. m. molossinus. Homozygous null mice exhibit alkalization of the hippocampal hilus, leading to reduced miniature inhibitory postsynaptic current amplitude of granule cells and induction of depression-like and anxiety behaviors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
