| Primary Identifier | MGI:1349183 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 18829 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables CCR7 chemokine receptor binding activity and chemokine activity. Involved in several processes, including dendritic cell dendrite assembly; negative regulation of dendritic cell dendrite assembly; and positive regulation of T cell chemotaxis. Acts upstream of or within induction of positive chemotaxis and lymph node development. Predicted to be active in extracellular space. Is expressed in branchial arch; hemolymphoid system; renal vasculature; and trunk. Orthologous to human CCL21 (C-C motif chemokine ligand 21). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired negative T cell selection with small thymus medulla, decreased thymic B cells and autoimmune dacryoadenitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
