Primary Identifier | MGI:1343051 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 11470 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in acrosome assembly and fertilization. Located in acrosomal vesicle; male germ cell nucleus; and motile cilium. Colocalizes with Golgi apparatus. Human ortholog(s) of this gene implicated in male infertility and spermatogenic failure 86. Orthologous to human ACTL7A (actin like 7A). PHENOTYPE: Mcie homozygous for a null allele exhibit male infertility associated with acrosomal ultrastructural defects. [provided by MGI curators] |