| Primary Identifier | MGI:3041206 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 232827 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable several functions, including Pyrin domain binding activity; aspartic-type endopeptidase inhibitor activity; and caspase binding activity. Predicted to be involved in regulation of inflammatory response. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including 2-cell stage conceptus; 4-8 cell stage conceptus; blastocyst-stage conceptus; gonad; and morula-stage conceptus. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to several human genes including NLRP2 (NLR family pyrin domain containing 2). PHENOTYPE: Knockout mice exhibit no overt abnormal phenotypes. Older mice (greater than 15 weeks of age) females mice exhibit reduced fertility with abnormal ovarian follicles, irregularly formed oocytes and decreased fertilization rates. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
