Primary Identifier | MGI:1098219 | Organism | mouse, laboratory |
Chromosome | X | NCBI Gene Number | 15354 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity and RNA binding activity. Acts upstream of or within negative regulation of B cell differentiation and negative regulation of myeloid cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; ear; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in syndromic microphthalmia 13. Orthologous to human HMGB3 (high mobility group box 3). PHENOTYPE: Homozygous null mice display increased red cell numbers, hematocrit, and hemaglobin content, and decreased mean red cell volume and common myeloid and lymphoid progenitors. [provided by MGI curators] |