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Protein Coding Gene : Hmgb3 high mobility group box 3

Primary Identifier  MGI:1098219 Organism  mouse, laboratory
Chromosome  X NCBI Gene Number  15354
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables DNA binding activity and RNA binding activity. Acts upstream of or within negative regulation of B cell differentiation and negative regulation of myeloid cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; ear; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in syndromic microphthalmia 13. Orthologous to human HMGB3 (high mobility group box 3).
PHENOTYPE: Homozygous null mice display increased red cell numbers, hematocrit, and hemaglobin content, and decreased mean red cell volume and common myeloid and lymphoid progenitors. [provided by MGI curators]
  • synonyms:
  • high mobilty group protein 2A,
  • Hmgb3,
  • Hmg4,
  • high-mobility group protein 4,
  • Hmg2a,
  • MGI:1276532,
  • high mobility group box 3

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

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0 Involved In Mutations

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For