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Protein Coding Gene : Gab3 growth factor receptor bound protein 2-associated protein 3
Primary Identifier  MGI:2387324 Organism  mouse, laboratory
Chromosome  X NCBI Gene Number  210710
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable signaling adaptor activity. Acts upstream of or within macrophage differentiation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human GAB3 (GRB2 associated binding protein 3).
PHENOTYPE: Females homozygous and males hemizygous for disruptions in this X-linked gene developed normally, exhibited normal hematopoiesis, and were immunocompetent. Homozygosity for a KO or critical point mutation affects NK cell function and increases pregnancy/birth failures. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 5930433H21 gene,
  • Gab3,
  • 5930433H21Rik,
  • MGI:2445045,
  • growth factor receptor bound protein 2-associated protein 3
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