Primary Identifier | MGI:4413733 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 102467638 |
Mgi Type | tRNA gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables AGA codon-amino acid adaptor activity. Acts upstream of or within negative regulation of synaptic transmission and translational elongation. PHENOTYPE: Mice homozygous for a spontaneous C-to-T transition, found in C57BL/6J and C57BL/6JEiJ but not other inbred strains, display abnormal translational elongation. Homozygous KO in the C57BL/6NJ strain leads to increased resistance to chemically induced seizures similar to the B6J strain, which naturally carries a defective allele that also protects against electrically induced seizures. [provided by MGI curators] |