Primary Identifier | MGI:2685728 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 380709 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including fertilization; meiosis I cell cycle process; and regulation of meiotic cell cycle. Located in chromosome. Is expressed in ileum; male reproductive gland or organ; and ovary. Orthologous to human SPATA22 (spermatogenesis associated 22). PHENOTYPE: Homozygous mutations of this gene result in small gonads, severe germ cell depletion, and sterility in both males and females due to meiotic prophase I arrest associated with abnormal synaptonemal complex formation, chromosome asynapsis, and impaired double strand break repair. [provided by MGI curators] |