| Primary Identifier | MGI:2678948 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 231003 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable POZ domain binding activity; actin filament binding activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in actin cytoskeleton organization; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation protein catabolic process at postsynapse. Predicted to be located in actin cytoskeleton; dendrite cytoplasm; and neuronal cell body. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynapse. Orthologous to human KLHL17 (kelch like family member 17). PHENOTYPE: Mice homozygous and heterozygous for a null allele exhibit reduced width of dendritic spine heads in neurons. Heterozygotes also show slightly increased mEPSC amplitude, hyperactivity and increased rearing, and reduced social interaction. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
