| Primary Identifier | MGI:106210 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 12945 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables zymogen binding activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Acts upstream of or within inner cell mass cell proliferation; positive regulation of epithelial cell differentiation; and response to bacterium. Located in extracellular matrix and zymogen granule membrane. Is expressed in several structures, including blastocyst; central nervous system; genitourinary system; gut; and notochord. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human DMBT1 (deleted in malignant brain tumors 1). PHENOTYPE: Mice homozygous for one null allele display embryonic lethality and an abnormal inner cell mass. Mice homozygous for a different null allele are viable and fertile with an increased susceptibility to induced colitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
