| Primary Identifier | MGI:95683 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 14559 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cytokine activity. Acts upstream of or within several processes, including endoderm development; in utero embryonic development; and mesoderm development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including embryo mesoderm; future midbrain; genitourinary system; nervous system; and primitive streak. Used to study annular pancreas. Human ortholog(s) of this gene implicated in congenital heart disease; multiple types of congenital heart defects 6; and visceral heterotaxy. Orthologous to human GDF1 (growth differentiation factor 1). PHENOTYPE: Homozygous null mice display partially penetrant late embryonic lethality, neonatal lethality, situs inversus, right pulmonary isomerism, and other left-right patterning defects, cardiac septal defects, annular pancreas, and abnormal spleen morphology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
