First Author | Kim JM | Year | 1992 |
Journal | J Immunol | Volume | 148 |
Issue | 11 | Pages | 3618-23 |
PubMed ID | 1350294 | Mgi Jnum | J:1031 |
Mgi Id | MGI:49563 | Doi | 10.4049/jimmunol.148.11.3618 |
Citation | Kim JM, et al. (1992) Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes. J Immunol 148(11):3618-23 |
abstractText | The nucleotide sequence of a 7.2-kb segment containing the mouse IL-10 (mIL-10) gene was determined. Comparison to the mIL-10 cDNA sequence (Moore, K. W., et al. 1990. Science 248:1230; 250:494) revealed the presence of five exons that span approximately 5.1 kb of genomic DNA. The noncoding regions of the mIL-10 gene contain sequences that have been associated with transcriptional regulation of several cytokine genes. The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1. |