| First Author | Chacko GW | Year | 1996 |
| Journal | J Immunol | Volume | 157 |
| Issue | 6 | Pages | 2234-8 |
| PubMed ID | 8805618 | Mgi Jnum | J:35425 |
| Mgi Id | MGI:82874 | Doi | 10.4049/jimmunol.157.6.2234 |
| Citation | Chacko GW, et al. (1996) Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP. J Immunol 157(6):2234-8 |
| abstractText | Stimulation of the B cell Ag receptor (BCR) has been reported to induce tyrosine phosphorylation of a 145-kDa protein and its association with the adapter protein Shc. We have identified this protein as the novel inositol polyphosphate 5-phosphatase (SHIP). Further analysis revealed that both maximal phosphorylation of SHIP and its association with Shc require co-clustering with the Fc receptor for IgG (Fc gamma RII) rather than stimulation of the BCR alone. Since co-clustering of the BCR and Fc gamma RII also down-regulates proliferation induced by Ag receptor stimulation, we hypothesize that tyrosine phosphorylation of SHIP and its association with Shc contribute to negative signaling through effects on inositol and phosphatidylinositol metabolism. |
