| First Author | Nakaji T | Year | 1999 |
| Journal | Cancer Lett | Volume | 147 |
| Issue | 1-2 | Pages | 139-47 |
| PubMed ID | 10660099 | Mgi Jnum | J:60786 |
| Mgi Id | MGI:1353901 | Doi | 10.1016/s0304-3835(99)00285-2 |
| Citation | Nakaji T, et al. (1999) A new member of the GTPase superfamily that is upregulated in highly metastatic cells. Cancer Lett 147(1-2):139-47 |
| abstractText | Two sublines of B16 melanoma cells, F10 and BL6, are metastatic after intravenous injection, but only BL6 cells are metastatic after subcutaneous injection. We found a new member of the GTPase superfamily, namely TIB929, which displayed an induction of expression in BL6 cells. It conserved three consensus sequences for GTP-binding site motifs and showed a significant homology to the yeast Gtr2 gene throughout the coding sequence. TIB929 was expressed ubiquitously in human tumor cells, with a marked expression in highly metastatic cells. TIB929 was mapped on mouse chromosome 4D, syntenic to human chromosome 1p. The results suggested an involvement of TIB929 in malignant progression. |
