| First Author | Šošić D | Year | 2003 |
| Journal | Cell | Volume | 112 |
| Issue | 2 | Pages | 169-80 |
| PubMed ID | 12553906 | Mgi Jnum | J:81485 |
| Mgi Id | MGI:2449403 | Doi | 10.1016/s0092-8674(03)00002-3 |
| Citation | Sosic D, et al. (2003) Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell 112(2):169-80 |
| abstractText | During Drosophila embryogenesis, the dorsal transcription factor activates the expression of twist, a transcription factor required for mesoderm formation. We show here that the mammalian twist proteins, twist-1 and -2, are induced by a cytokine signaling pathway that requires the dorsal-related protein RelA, a member of the NF-kappaB family of transcription factors. Twist-1 and -2 repress cytokine gene expression through interaction with RelA. Mice homozygous for a twist-2 null allele or doubly heterozygous for twist-1 and -2 alleles show elevated expression of proinflammatory cytokines, resulting in perinatal death from cachexia. These findings reveal an evolutionarily conserved signaling circuit in which twist proteins regulate cytokine signaling by establishing a negative feedback loop that represses the NF-kappaB-dependent cytokine pathway. |
