| First Author | Wu T | Year | 2002 |
| Journal | J Virol | Volume | 76 |
| Issue | 5 | Pages | 2279-86 |
| PubMed ID | 11836406 | Mgi Jnum | J:74617 |
| Mgi Id | MGI:2158876 | Doi | 10.1128/jvi.76.5.2279-2286.2002 |
| Citation | Wu T, et al. (2002) Genetic control of a mouse serum lipoprotein factor that inactivates murine leukemia viruses: evaluation of apolipoprotein f as a candidate. J Virol 76(5):2279-86 |
| abstractText | Mice contain a serum factor capable of inactivating some subgroups of murine leukemia viruses. This leukemia virus-inactivating factor (LVIF) is distinct from immunoglobulin and complement; it has been associated with lipoprotein serum fractions and may be an apolipoprotein. The present study demonstrates that some Swiss-derived inbred strains are LVIF negative. Genetic crosses show this factor to be under control of a single gene that maps to distal chromosome 10 at or near the gene encoding a minor serum apolipoprotein, apolipoprotein F (ApoF). To evaluate this gene as a potential candidate for LVIF, the mouse ApoF gene was cloned and sequenced and its expression was assessed in LVIF-positive and -negative mice; no obvious differences were detected, suggesting that LVIF is under the control of a distinct linked gene. |
