| First Author | Shing Y | Year | 1993 |
| Journal | Science | Volume | 259 |
| Issue | 5101 | Pages | 1604-7 |
| PubMed ID | 8456283 | Mgi Jnum | J:22281 |
| Mgi Id | MGI:70162 | Doi | 10.1126/science.8456283 |
| Citation | Shing Y, et al. (1993) Betacellulin: a mitogen from pancreatic beta cell tumors. Science 259(5101):1604-7 |
| abstractText | Betacellulin, a member of the epidermal growth factor family, has been identified in the conditioned medium of cell lines derived from mouse pancreatic beta cell tumors. Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. The carboxyl-terminal domain of betacellulin has 50 percent sequence similarity with that of rat transforming growth factor alpha. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. |
