| First Author | James R | Year | 1991 |
| Journal | J Biol Chem | Volume | 266 |
| Issue | 5 | Pages | 3246-51 |
| PubMed ID | 1671571 | Mgi Jnum | J:10984 |
| Mgi Id | MGI:59426 | Doi | 10.1016/s0021-9258(18)49981-4 |
| Citation | James R, et al. (1991) Homeobox gene expression in the intestinal epithelium of adult mice. J Biol Chem 266(5):3246-51 |
| abstractText | Using a polymerase chain reaction-based strategy, we have detected the expression of nine different homeobox genes in adult mouse intestine. Included among these are the recently described intestine-specific Cdx-1 gene and a new, related gene, Cdx-2. Southern blot experiments show that Cdx-2 is present in a single copy in the mouse genome. Of several adult mouse tissues assayed, intestine was the only one that contained detectable levels of Cdx-2 mRNA. Expression of all nine homeobox genes in different regions of the intestine was quantitated by RNase protection analysis, which revealed a unique expression profile for each gene. These observations suggest that homeobox gene expression may play an important role in cellular differentiation in the adult intestine. |
