| First Author | Nishizawa M | Year | 1991 |
| Journal | FEBS Lett | Volume | 282 |
| Issue | 1 | Pages | 95-7 |
| PubMed ID | 1709121 | Mgi Jnum | J:30068 |
| Mgi Id | MGI:78751 | Doi | 10.1016/0014-5793(91)80452-9 |
| Citation | Nishizawa M, et al. (1991) Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1. FEBS Lett 282(1):95-7 |
| abstractText | Granulocyte colony-stimulating factor (G-CSF) is produced from macrophages in response to lipopolysaccharide (LPS). GPE1, a cis-acting element of the G-CSF gene promoter, functioned as an LPS-inducible element. We isolated cDNA and a chromosomal gene encoding the mouse GPE1-binding protein (GPE1-BP). A 150-amino acid protein deduced from the cDNA has a basic domain and a leucine zipper motif, and seems to be identical to that of recently isolated Ig/EBP. The nuclear extract from COS cells transfected with the cDNA showed GPE1-binding activity. Transcripts were ubiquitously detected, and may be spliced from two exons of a single gene. |
