| First Author | Wissenbach U | Year | 1998 |
| Journal | Biol Chem | Volume | 379 |
| Issue | 1 | Pages | 45-50 |
| PubMed ID | 9504716 | Mgi Jnum | J:46501 |
| Mgi Id | MGI:1201248 | Doi | 10.1515/bchm.1998.379.1.45 |
| Citation | Wissenbach U, et al. (1998) The structure of the murine calcium channel gamma-subunit gene and protein. Biol Chem 379(1):45-50 |
| abstractText | The gamma-subunit of voltage-gated calcium channels is a membrane protein that is associated with the skeletal muscle type of voltage gated calcium channels. Using a subunit-specific polyclonal antibody, the gamma-protein was detected in mouse skeletal muscle but not in brain, where at least five additional types of voltage-gated calcium channels are expressed. Murine genomic clones containing the full coding sequence of the gamma-subunit were isolated, the exons were mapped and sequenced. The murine gamma-subunit is encoded by a single copy gene containing 4 translated exons which are distributed over approximately 14 kilobases of DNA. The intron placement within the mouse gene correlates with the previously revealed organization of the human gamma-subunit gene, although the primary structures of the gamma- subunits are only moderately conserved between the murine, human, rat and rabbit proteins (75% identity). |
