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Publication : Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes.

First Author  Thomas PM Year  2001
Journal  DNA Seq Volume  12
Issue  2 Pages  131-5
PubMed ID  11761712 Mgi Jnum  J:71012
Mgi Id  MGI:2148948 Doi  10.3109/10425170109047567
Citation  Thomas PM, et al. (2001) Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes. DNA Seq 12(2):131-5
abstractText  We report the cloning, genomic organization and sequence of the mouse alpha-CALC and beta-CALC genes. The two genes share extensive sequence homology. The transcription units of both genes contain 6 exons. Transcripts of the alpha-CALC gene were found to alternatively include exon 4 or exons 5 and 6. For the beta-CALC gene exon 4 was not detected in transcripts derived from this gene. The predicted mouse alpha-CGRP was found to be identical to rat alpha-CGRP, however, beta-CGRP predicted amino acid sequences revealed three amino acid differences suggesting these residues are not critical to CGRP function.
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