| First Author | Banko JL | Year | 2007 |
| Journal | Neurobiol Learn Mem | Volume | 87 |
| Issue | 2 | Pages | 248-56 |
| PubMed ID | 17029989 | Mgi Jnum | J:128841 |
| Mgi Id | MGI:3768180 | Doi | 10.1016/j.nlm.2006.08.012 |
| Citation | Banko JL, et al. (2007) Behavioral alterations in mice lacking the translation repressor 4E-BP2. Neurobiol Learn Mem 87(2):248-56 |
| abstractText | The requirement for de novo protein synthesis during multiple forms of learning, memory and behavior is well-established; however, we are only beginning to uncover the regulatory mechanisms that govern this process. In order to determine how translation initiation is regulated during neuroplasticity we engineered mutant C57Bl/6J mice that lack the translation repressor eukaryotic initiation factor 4E-binding protein 2 (4E-BP2) and have previously demonstrated that 4E-BP2 plays a critical role in hippocampus-dependent synaptic plasticity and memory. Herein, we examined the 4E-BP2 knockout mice in a battery of paradigms to address motor activity and motor skill learning, anxiety and social dominance behaviors, working memory and conditioned taste aversion. We found that the 4E-BP2 knockout mice demonstrated altered activity in the rotating rod test, light/dark exploration test, spontaneous alternation T-maze and conditioned taste aversion test. The information gained from these studies builds a solid foundation for future studies on the specific role of 4E-BP2 in various types of behavior, and for a broader, more detailed examination of the mechanisms of translational control in the brain. |
