| First Author | Monaco L | Year | 2003 |
| Journal | Gene | Volume | 321 |
| Pages | 57-63 | PubMed ID | 14636992 |
| Mgi Jnum | J:86829 | Mgi Id | MGI:2682144 |
| Doi | 10.1016/s0378-1119(03)00834-5 | Citation | Monaco L, et al. (2003) Genomic structure and transcriptional regulation of Che-1, a novel partner of Rb. Gene 321:57-63 |
| abstractText | We recently identified and cloned a novel human gene, Che-1, whose product interacts with both RNA polymerase II and the retinoblastoma gene product (Rb). Furthermore, we found that Che-1 overexpression counteracts the growth inhibitory effects of Rb, regulating in such way both transcription and cell proliferation. In this paper, we describe the genomic organization of the mouse orthologous Che-1 gene and its promoter region. The promoter is TATA less and presents several potential transcription factor-binding motifs. Importantly, we showed that Che-1 expression is regulated by a negative feedback mechanism, in which this protein is present on its own promoter repressing transcription. |
