| First Author | De Zeeuw CI | Year | 1997 |
| Journal | Neuron | Volume | 19 |
| Issue | 6 | Pages | 1187-99 |
| PubMed ID | 9427243 | Mgi Jnum | J:45192 |
| Mgi Id | MGI:1194531 | Doi | 10.1016/s0896-6273(00)80411-0 |
| Citation | De Zeeuw CI, et al. (1997) CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies. Neuron 19(6):1187-99 |
| abstractText | Intracellular localization of organelles may depend in part on specific cytoplasmic linker proteins (CLIPs) that link membranous organelles to microtubules. Here, we characterize rat cDNAs encoding a novel, brain-specific CLIP of 115 kDa. This protein contains two N-terminal microtubule-binding domains and a long coiled-coil region; it binds to microtubules and is homologous to CLIP-170, a protein mediating the binding of endosomes to microtubules. CLIP-115 is enriched in the dendritic lamellar body (DLB), a recently discovered organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. Local microtubule depolymerization leads to a temporary reduction of DLBs. These results suggest that CLIP-115 operates in the control of brain-specific organelle translocations. |
