| First Author | Reboldi A | Year | 2016 |
| Journal | Science | Volume | 352 |
| Issue | 6287 | Pages | aaf4822 |
| PubMed ID | 27174992 | Mgi Jnum | J:233674 |
| Mgi Id | MGI:5787846 | Doi | 10.1126/science.aaf4822 |
| Citation | Reboldi A, et al. (2016) IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science 352(6287):aaf4822 |
| abstractText | Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer's patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B cells use the chemokine receptor CCR6 to access the subepithelial dome (SED) of PPs. There, B cells undergo prolonged interactions with SED dendritic cells (DCs). PP IgA class switching requires innate lymphoid cells, which promote lymphotoxin-beta receptor (LTbetaR)-dependent maintenance of DCs. PP DCs augment IgA production by integrin alphavbeta8-mediated activation of transforming growth factor-beta (TGFbeta). In mice where B cells cannot access the SED, IgA responses against oral antigen and gut commensals are impaired. These studies establish the PP SED as a niche supporting DC-B cell interactions needed for TGFbeta activation and induction of mucosal IgA responses. |
