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Publication : Conservation of the Duchenne muscular dystrophy gene in mice and humans.

First Author  Hoffman EP Year  1987
Journal  Science Volume  238
Issue  4825 Pages  347-50
PubMed ID  3659917 Mgi Jnum  J:8862
Mgi Id  MGI:57327 Doi  10.1126/science.3659917
Citation  Hoffman EP, et al. (1987) Conservation of the Duchenne muscular dystrophy gene in mice and humans. Science 238(4825):347-50
abstractText  A portion of the Duchenne muscular dystrophy (DMD) gene transcript from human fetal skeletal muscle and mouse adult heart was sequenced, representing approximately 25 percent of the total, 14-kb DMD transcript. The nucleic acid and predicted amino acid sequences from the two species are nearly 90 percent homologous. The amino acid sequence that is predicted from this portion of the DMD gene indicates that the protein product might serve a structural role in muscle, but the abundance and tissue distribution of the messenger RNA suggests that the DMD protein is not nebulin.
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