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Publication : The nucleotide sequence of three genes participating in the adipose differentiation of 3T3 cells.

First Author  Phillips M Year  1986
Journal  J Biol Chem Volume  261
Issue  23 Pages  10821-7
PubMed ID  3015943 Mgi Jnum  J:34536
Mgi Id  MGI:81992 Doi  10.1016/s0021-9258(18)67461-7
Citation  Phillips M, et al. (1986) The nucleotide sequence of three genes participating in the adipose differentiation of 3T3 cells. J Biol Chem 261(23):10821-7
abstractText  When 3T3 cells undergo adipose differentiation, they are reprogrammed by changes in gene expression of sufficient magnitude to greatly alter the protein composition of the cells. Three participating genes encode glycerophosphate dehydrogenase, a lipid-binding protein, and a serine protease. These three genes have now been cloned and sequenced. Their exon/intron structures are described, together with some interesting peculiarities and some regions of common sequence. It remains to be demonstrated whether the information for common participation of the genes in the program of differentiation resides in controlling elements within the regions sequenced.
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