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Publication : Structural organization and chromosome location of the mouse elongin A gene (Tceb3).

First Author  Aso T Year  1999
Journal  Cytogenet Cell Genet Volume  86
Issue  3-4 Pages  259-62
PubMed ID  10575222 Mgi Jnum  J:58555
Mgi Id  MGI:1349214 Doi  10.1159/000015355
Citation  Aso T, et al. (1999) Structural organization and chromosome location of the mouse elongin A gene (Tceb3). Cytogenet Cell Genet 86(3-4):259-62
abstractText  Elongin A is the transcriptionally active subunit of the Elongin complex, which strongly increases the rate of elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites within transcription units. In the present study, we obtained the cDNA sequence of the mouse Elongin A gene (Tceb3) and characterized its genomic structure. The deduced 773-amino acid sequence of mouse Elongin A shows 91% and 81% identity with rat and human Elongin A, respectively. The Elongin A gene was mapped to mouse chromosome 4D3 by fluorescence in situ hybridization.
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