| First Author | Vindedal GF | Year | 2016 |
| Journal | Mol Cell Neurosci | Volume | 77 |
| Pages | 47-52 | PubMed ID | 27751903 |
| Mgi Jnum | J:260928 | Mgi Id | MGI:6152210 |
| Doi | 10.1016/j.mcn.2016.10.004 | Citation | Vindedal GF, et al. (2016) Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation. Mol Cell Neurosci 77:47-52 |
| abstractText | There is a constitutive production of water in brain. The efflux routes of this excess water remain to be identified. We used basal brain water content as a proxy for the capacity of water exit routes. Basal brain water content was increased in mice with a complete loss of aquaporin-4 (AQP4) water channels (global Aqp4(-/-) mice), but not in mice with a selective removal of perivascular AQP4 or in a novel mouse line with a selective deletion of ependymal AQP4 (Foxj1-Cre:Aqp4(flox/flox) mice). Unique for the global Aqp4(-/-) mice is the loss of the AQP4 pool subjacent to the pial membrane. Our data suggest that water accumulates in brain when subpial AQP4 is missing, pointing to a critical role of this pool of water channels in brain water exit. |
