| First Author | Akatsuka H | Year | 2017 |
| Journal | Biochem Biophys Res Commun | Volume | 491 |
| Issue | 4 | Pages | 1098-1104 |
| PubMed ID | 28789945 | Mgi Jnum | J:251412 |
| Mgi Id | MGI:6103573 | Doi | 10.1016/j.bbrc.2017.08.019 |
| Citation | Akatsuka H, et al. (2017) AMBRA1 is involved in T cell receptor-mediated metabolic reprogramming through an ATG7-independent pathway. Biochem Biophys Res Commun 491(4):1098-1104 |
| abstractText | Metabolic reprogramming contributes to dynamic alteration of cell functions and characteristics. In T cells, TCR-mediated signaling evokes metabolic reprogramming and autophagy. AMBRA1 is known to serve in the facilitation of autophagy and quality control of mitochondria, but the role of AMBRA1 in T cell metabolic alteration is unknown. Here, we show that AMBRA1, but not ATG7, plays a role in TCR-mediated control of glycolytic factors and mitochondrial mass, while both AMBRA1 and ATG7 are required for autolysosome formation. Our results suggested that AMBRA1 is a core factor that controls both autophagy and metabolic regulation. |
