| First Author | Kang AD | Year | 1996 |
| Journal | Infect Immun | Volume | 64 |
| Issue | 11 | Pages | 4612-7 |
| PubMed ID | 8890215 | Mgi Jnum | J:38186 |
| Mgi Id | MGI:85574 | Doi | 10.1128/iai.64.11.4612-4617.1996 |
| Citation | Kang AD, et al. (1996) Restoration of lipopolysaccharide-mediated B-cell response after expression of a cDNA encoding a GTP-binding protein. Infect Immun 64(11):4612-7 |
| abstractText | Previous analysis of hybrid progeny derived from lipopolysaccharide (LPS) responder and nonresponder inbred mouse strains demonstrated that a single genetic locus controlled responsiveness to LPS. Using a differential functional screening approach, we report the isolation of a cDNA that has sequence homology to a GTP-binding protein. Expression of the cDNA in splenic B cells of C3H/HeJ nonresponder, endotoxin-resistant mice resulted in polyclonal B-cell activation in response to LPS stimulation. Thus a GTP-binding protein may be involved in LPS stimulation in B cells and perhaps other cell types. |
