| First Author | Takahashi M | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 5 | Pages | 573-8 |
| PubMed ID | 18242188 | Mgi Jnum | J:202588 |
| Mgi Id | MGI:5520045 | Doi | 10.1016/j.febslet.2008.01.023 |
| Citation | Takahashi M, et al. (2008) Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Lett 582(5):573-8 |
| abstractText | To explore a novel adipokine, we screened adipocyte differentiation-related gene and found that TIG2/chemerin was strongly induced during the adipocyte differentiation. Chemerin was secreted by the mature 3T3-L1 adipocytes and expressed abundantly in adipose tissue in vivo as recently described. Intriguingly, the expression of chemerin was differently regulated in the liver and adipose tissue in db/db mice. In addition, serum chemerin concentration was decreased in db/db mice. Chemerin and its receptor/ChemR23 were expressed in mature adipocytes, suggesting its function in autocrine/paracrine fashion. Finally, chemerin potentiated insulin-stimulated glucose uptake concomitant with enhanced insulin signaling in the 3T3-L1 adipocytes. These data establish that chemerin is a novel adipokine that regulates adipocyte function. |
