| First Author | Kung SK | Year | 1999 |
| Journal | J Immunol | Volume | 162 |
| Issue | 10 | Pages | 5876-87 |
| PubMed ID | 10229823 | Mgi Jnum | J:54975 |
| Mgi Id | MGI:1336838 | Doi | 10.4049/jimmunol.162.10.5876 |
| Citation | Kung SK, et al. (1999) The NKR-P1B gene product is an inhibitory receptor on SJL/J NK cells. J Immunol 162(10):5876-87 |
| abstractText | The mouse NKR-P1 family includes at least three genes: NKR-P1A, -B, -C. Neither surface expression nor function of the NKR-P1B gene product has previously been shown. Here, we demonstrate that the SJL/J allele of the NKR-P1B gene product is expressed on SJL/J NK cells, and is recognized by PK136 mAb. Interestingly, the same mAb does not recognize the NKR-P1B gene product of C57BL/6. We have also generated a novel mAb, 1C10, that recognizes an activation receptor on SJL/J NK cells. Activation of the NKR-P1B receptor-inhibited 1C10 mAb induced redirected lysis and recruited SHP-1, indicating that NKR-P1B is an inhibitory receptor. Therefore, the mouse NKR-P1 gene family, like the Ly49 family, includes both activation and inhibitory receptors. |
