| First Author | Zhang Y | Year | 2009 |
| Journal | Blood | Volume | 113 |
| Issue | 7 | Pages | 1455-63 |
| PubMed ID | 18818388 | Mgi Jnum | J:145449 |
| Mgi Id | MGI:3834770 | Doi | 10.1182/blood-2008-05-159905 |
| Citation | Zhang Y, et al. (2009) MLL5 contributes to hematopoietic stem cell fitness and homeostasis. Blood 113(7):1455-63 |
| abstractText | MLL5 is a novel trithorax group gene and a candidate tumor suppressor gene located within a 2.5-Mb interval of chromosome band 7q22 that frequently is deleted in human myeloid malignancy. Here we show that inactivation of the Mll5 gene in mice results in a 30% reduction in the average representation of hematopoietic stem cells and in functional impairment of long-term hematopoietic repopulation potential under competitive conditions. Bone marrow cells from Mll5-deficient mice were defective in spleen colony-forming assays, and the mutant mice showed enhanced susceptibility to 5-fluorouracil-induced myelosuppression. Heterozygous and homozygous Mll5 mutant mice did not spontaneously develop hematologic cancers, and loss of Mll5 did not alter the phenotype of a fatal myeloproliferative disorder induced by oncogenic Kras in vivo. Collectively, the data reveal an important role for Mll5 in HSC homeostasis and provide a basis for further studies to explore its role in leukemogenesis. |
