| First Author | Travis A | Year | 1991 |
| Journal | Genes Dev | Volume | 5 |
| Issue | 5 | Pages | 880-94 |
| PubMed ID | 1827423 | Mgi Jnum | J:12923 |
| Mgi Id | MGI:61139 | Doi | 10.1101/gad.5.5.880 |
| Citation | Travis A, et al. (1991) LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] [published erratum appears in Genes Dev 1991 Jun;5(6):following 1113]. Genes Dev 5(5):880-94 |
| abstractText | Lymphoid-specific cDNA clones were isolated that encode a nuclear protein with homology to the chromosomal nonhistone protein HMG-1 and to putative regulators of cell specialization, including the mammalian testis-determining factor SRY and fungal mating-type proteins. The gene represented by the isolated cDNA clones, termed LEF-1 (lymphoid enhancer-binding factor 1), is developmentally regulated and expressed in pre-B and T lymphocytes but not in later-stage B cells or nonlymphoid tissues. Both endogenous and recombinant LEF-1 were shown to bind to a functionally important site in the T-cell antigen receptor (TCR) alpha enhancer. Maximal TCR alpha enhancer activity was found to parallel the cell type-specific expression pattern of LEF-1. Moreover, forced expression of recombinant LEF-1 in late stage B cells increases TCR alpha enhancer function. Taken together, these data suggest that LEF-1 is a regulatory participant in lymphocyte gene expression and differentiation. |
