| First Author | Okamoto K | Year | 1994 |
| Journal | EMBO J | Volume | 13 |
| Issue | 20 | Pages | 4816-22 |
| PubMed ID | 7957050 | Mgi Jnum | J:21236 |
| Mgi Id | MGI:69260 | Doi | 10.1002/j.1460-2075.1994.tb06807.x |
| Citation | Okamoto K, et al. (1994) Cyclin G is a transcriptional target of the p53 tumor suppressor protein. EMBO J 13(20):4816-22 |
| abstractText | Through a PCR-based differential screening method, cyclin G was identified as a novel transcriptional target of the p53 tumor suppressor gene product. In both a mouse p53 temperature-sensitive leukemic cell line and mouse embryonic fibroblasts (MEF) after gamma-irradiation, cyclin G mRNA was rapidly induced. MEF from a p53-deficient mouse expressed cyclin G at a level > 10-fold lower than that from a wild-type mouse. Using a DNA binding assay, a specific p53 binding site was identified upstream from the cyclin G gene, which functioned as a p53-dependent cis-acting element in a transient transfection assay. These results suggest that cyclin G might participate in a p53-mediated pathway to prevent tumorigenesis. |
