| First Author | Wong P | Year | 2013 |
| Journal | PLoS One | Volume | 8 |
| Issue | 5 | Pages | e63815 |
| PubMed ID | 23675506 | Mgi Jnum | J:200622 |
| Mgi Id | MGI:5508963 | Doi | 10.1371/journal.pone.0063815 |
| Citation | Wong P, et al. (2013) Targeted ANP32E mutant mice do not demonstrate obvious movement defects. PLoS One 8(5):e63815 |
| abstractText | BACKGROUND: The ANP32 family of proteins have been implicated in neuronal function through biochemical and cellular biology studies in neurons, as well as by recent behavioural studies of a gene-trapped loss-of-function mutation of Anp32e in mice, particularly with respect to fine motor function. A second targeted allele of the Anp32e, however, did not appear to demonstrate neurological phenotypes. METHODOLOGY/PRINCIPAL FINDINGS: Using a stringently controlled cohort of ten-generation backcrossed, co-caged, sex-matched, littermate pairs, we assayed for potential motor defects in the targeted ANP32E-deficient mice. We found no phenotypic difference in any assays. CONCLUSION: Since it is unlikely that the gene-trap is a more complete loss-of-function, our results suggest that ANP32E has no appreciable effect on motor functions and that genetic background differences most likely account for the gene-trap phenomena. |
