| First Author | Carraway KL 3rd | Year | 1997 |
| Journal | Nature | Volume | 387 |
| Issue | 6632 | Pages | 512-6 |
| PubMed ID | 9168115 | Mgi Jnum | J:42983 |
| Mgi Id | MGI:1096828 | Doi | 10.1038/387512a0 |
| Citation | Carraway KL 3rd, et al. (1997) Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature 387(6632):512-6 |
| abstractText | The neuregulins (NRGs) are a family of multipotent epidermal-growth-factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new ligands binds to both the ErbB3- and ErbB4-receptor tyrosine kinases. However, NRG-2 stimulates different ErbB-receptor tyrosine-phosphorylation profiles from NRG-1. Our results indicate that NRG-1 and NRG-2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biochemical responses in cells. |
